Results 121 to 130 of about 4,771,901 (306)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Qu'est-ce Que Texte Technique Veut Dire
Discourse and Writing/Rédactologie, 1996 Massiva N'Zafio
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Writing with imagination: A Practical Guide
, 2000 Review of Linda Aronson's 'Writing with ...
Bourke, Nicole A.
core
Collaborating upwards: Writing across hierarchal boundaries
, 2020 Ellison, ER ORCiD: 0000-0002-0865-950XAs a practice, collaborative writing between students and supervisors is hardly new and can be considered common in STEM disciplines.
Elizabeth Ellison (9794516) +3 more
core
Basic Functional Literacy for Engineering Students: Towards a Linguistic Definition
Discourse and Writing/Rédactologie, 1998 Michael P. Jordan
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Good Writing in Cross-cultural Context by Xiao-Ming Li
Discourse and Writing/Rédactologie, 1999 Shurli Makmillen, Yaying Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source