Results 61 to 70 of about 6,960,375 (326)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Fast algorithms for informed independent component/vector extraction

EURASIP Journal on Advances in Signal Processing
We propose new and efficient algorithms for semi-blind source extraction derived from the well-known FastICA for independent component analysis (ICA). The algorithms assume independence of the source of interest (SOI) and other signals in the mixture and
Zbyněk Koldovský, Jiří Málek, Jaroslav Čmejla, Martin Vrátný, Walter Kellermann   +4 more
doaj   +1 more source

How to Generate Security Cameras: Towards Defence Generation for Socio-Technical Systems [PDF]

, 2015
Recently security researchers have started to look into automated generation of attack trees from socio-technical system models. The obvious next step in this trend of automated risk analysis is automating the selection of security controls to treat the ...
Gadyatskaya, Olga
core   +4 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

A Pilot Study in Sensor Instrumented Training (SIT) - Ground Contact Time for Monitoring Fatigue and Curve Running Technique

International Journal of Computer Science in Sport
This study examines the possibilities of sensor-instrumented training (SIT) in mid-distance running training sessions. Within this framework, variations of ground contact time (GCT) between straight and curved running, as well as GCT as a fatigue ...
Blauberger P., Fukushima T., Russomanno T. G., Lames M.   +3 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Scientometric dimensions of technical reports from Bhabha Atomic Research Centre [PDF]

, 2002
Technical report is one of the media to record the scientific information generated by scientists and engineers, Bhabha Atomic Research Centre (BARC) published 554 technical reports during 1990-99 under the categories: External (373) and Internal (181 ...
Kalyane, V. L., Swarna, T., Vijai Kumar, *   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source