Results 91 to 100 of about 225,851 (312)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Ceramics from the scythian burial ground of Chineta-2 (Altai)
Поволжская археологияThe article presents the results of the study of ceramics discovered during the study of barrows of the Scythian-Saka period at the Chineta 2 burial ground, located in the Krasnoshchyokovo district of the Altai Krai. The site contains signs of the burial
Dashkovskiy Petr K. +1 more
doaj +1 more source
Analysis and Control of Technical Errors in Machining Technology
Frontiers in Science and EngineeringExcessive errors in the machining process affect the performance of mechanical products. In the study of analytical machinery.On the basis of the source of technical error in the processing technology, the source of error is determined, mainly including positioning error,machine tool manufacturing errors and tool geometric errors; The corresponding ...
openaire +1 more source
Stabilisation Targets, Technical Change and the Macroeconomic Costs of Climate Change Control [PDF]
The issue of greenhouse gas (GHG) stabilization stands on three critical open questions. Namely, what are the impacts deriving from different levels of climate change and their distribution.
Carlo Carraro +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Does Endogenous Technical Change Make a Difference in Climate Policy Analysis? A Robustness Exercise with the FEEM-RICE Model [PDF]
Technical change is generally considered the key to the solution of environmental problems, in particular global phenomena like climate change. Scientists differ in their views on the thaumaturgic virtues of technical change.
Carlo Carraro, Marzio Galeotti
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Ownership and Technological Capabilities in Brazil [PDF]
Over the last fifty years, foreign-owned firms have played an important role in developing the Brazilian industry. The focus of debate on the impacts of these firms upon technical change in Brazil has been on the use of technology.
Ionara Costa
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source