Results 51 to 60 of about 10,039,556 (320)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Education responses to climate change and quality : two parts of the same agenda? [PDF]

, 2010
Increasing attention to climate change and the current global economic crisis has underscored the need for approaches to education that equip and empower people of all ages to deal with uncertain environmental, economic and political futures.
Bangay, Colin, Blum, Nicole
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The influence of artistic techniques on the development of manual skills in a six year old child

Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej
Art education plays an important role in developing and shaping the child's sensitivity to the beauty of shapes and colors in the surrounding reality, which he learns through his senses, primarily sight and touch.
Anna Hojnor, Robert Sito, Piotr Migo, Joanna Jarczak, Wiesław Jaszczur   +4 more
doaj   +4 more sources

Efectos no deseados de la formación para el trabajo en la educación media colombiana Efeitos indesejáveis da formação para o trabalho no ensino secundário na Colômbia Unwanted Effects of Job Training in Secondary Education in Colombia

Educación y Educadores, 2010
La educación media estatal colombiana está pasando del nocivo extremo de reducirse a ser un puente para la educación universitaria, a otro igualmente negativo: el de formar en oficios de baja calificación o en competencias para el "autoempleo", pero sin ...
Claudia Milena Díaz-Ríos, Jorge Enrique Celis-Giraldo   +1 more
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Teacher change in a developing curriculum area: the example of trade teachers in the New Zealand technology curriculum [PDF]

, 2000
Technology education for all students is a relatively new phenomenon in national and international curricula. Although New Zealand has a long history of technical education in the senior primary and secondary school, a curriculum for technology education
Ewington, Louis, Jones, Alister
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evaluation of Laboratory Utilization at the Department of Civil Engineering, Andalas University in Enhancing Educational Services for External Parties

Edulab: Majalah Ilmiah Laboratorium Pendidikan
Purpose – This study aims to evaluate the utilization level of the Civil Engineering Department (DTS) laboratories at Universitas Andalas for educational and research activities, both internally and externally, as well as their implications for enhancing
Uci Mardiani, Sabril Haris HG, Refni Herman, Muhammad Al Hasbi Ashrief   +3 more
doaj   +1 more source