Results 111 to 120 of about 8,257,755 (349)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

DIRECT FREQUENCY CONVERTER WITH ARTIFICIAL AND NATURAL COMMUTATION FOR BRUSHLESS ASYNCHRONIZED MACHINES

Electrical engineering & Electromechanics, 2015
The comparative analysis of direct frequency converters with artificial and natural- switching term of the cyclical control algorithm is presented; the recommendations for their using in brushless asynchronized machines with three-phase winding are ...
А.М. Galynovskiy, E.А. Lenskaya, N.P. Melnik   +2 more
doaj  

Technical objects' ecological efficiency indicators control

Автоматизация технологических и бизнес-процессов, 2019
Traditional automatic control systems do not solve the task of limiting the harmful effects of technical objects on the environment. The problem is to increase the effectiveness of means of its protection against the harmful effects of industry. Relevant
S. A. Voinova
doaj   +1 more source

Technical Efficiency of Innovations in Poland from EU Perspective

Gospodarka Narodowa. The Polish Journal of Economics, 2019
This paper presents the results of an assessment of technical efficiency of innovations in European Union. Data Envelopment Analysis was used to investigate this subject.
Wojciech Nasierowski
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Microeconomic Reform and Technical Efficiency in Australian Manufacturing [PDF]

The technical efficiency dividend reaped by Australian manufacturing industries following the implementation of microeconomic reforms over the past three decades is analysed empirically in this paper.
Neil Dias Karunaratne
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Features of Structural–Phase Changes and Tribological Behavior of Tool Steel After Vacuum and Plasma Electrolytic Nitriding

Journal of Manufacturing and Materials Processing
Nitriding is one of the technologies used to improve the performance properties of tool steels. In addition to traditional gas nitriding, technologies aimed at increasing the productivity and/or efficiency of processing have found application in industry.
Marina A. Volosova, Sergei A. Kusmanov, Tatiana L. Mukhacheva, Ivan V. Tambovskiy, Artem O. Komarov, Andrey E. Smirnov, Svetlana F. Katerzhina, Igor V. Suminov, Sergey N. Grigoriev   +8 more
doaj   +1 more source