Results 141 to 150 of about 8,257,755 (349)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
TECHNICAL EFFICIENCY OF NEW YORK DAIRY FARMS
The technical efficiencies of New York dairy farms were estimated using a frontier production function. The average farm was 69 percent efficient. Individual farm efficiency was regressed on variables not considered inputs to explain why a farm was not ...
Tauer, Loren W., Belbase, Krishna P.
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Technical Change, Technical Efficiency, and Their Impact on Input Demand in the Agricultural and Manufacturing Sectors of Pakistan [PDF]
Technical change has been considered as one of the most important determinants of economic growth. In developed economies, a proportionately higher percentage of GDP growth is attributable to technological progress and technical efficiency.
Karamat Ali, Abdul Hamid
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Technical Efficiency of Hospitals in Tehran, Iran.
Iranian journal of public health, 2016 Nowadays, restriction on access and optimum use of resources is the main challenge of development in all organizations. Therefore, the aim of this study was to determine the technical efficiency and its factors, influencing hospitals of Tehran.This research was a descriptive-analytical and retrospective study conducted in 2014-2015. Fifty two hospitals
Edris KAKEMAM +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
CHARACTERISATION AND TECHNICAL EFFICIENCY OF PORTUGUESE WINE FARMS
This study aims to characterise the evolution of vineyard production, to measure the levels of technical efficiency, and to relate these with farmers and farms attributes. The sample used is composed of a panel of vineyard farms, for the period 2000-2005,
Costa, Fatima +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
MEASUREMENT AND EXPLANATION OF TECHNICAL EFFICIENCY IN MISSOURI HOG PRODUCTION
The U.S. live hog production has undergone a significant structural change characterized by a trend toward larger operations. Experts argue that there is a cost advantage for larger farms due to industrialization and increased management intensity.
Ben-Belhassen, Boubaker +1 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Technical efficiency in Botswana’s financial institutions: a DEA approach [PDF]
This paper examines technical and pure technical efficiencies of ten major financial institutions in Botswana for each year during the period 2001-2006 using data envelopment analysis.
Moffat, Boitnmelo, Valadkhani, Abbas
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