Results 141 to 150 of about 6,118,389 (306)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A produção de cereais em uma propriedade no município de Chapecó - SC The production of grain in small properties: a case study in the city of Chapecó - SC, Brazil

Ciência Rural, 2013
O presente artigo aborda uma análise da produção de cereais em uma propriedade rural no município de Chapecó-SC. A coleta dos dados foi realizada considerando o cultivo da soja, do trigo e do milho, durante as safras 2008/2009, 2009/2010 e 2010/2011 ...
Odimar Ozelame, Tanice Andreatta
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Land Rights Indicators in the Post-2015 SDGs: Recommendations for the inter-agency expert group and other policymakers

, 2015
This briefing makes recommendations for those working on the land rights aspect of the post-2015 agenda. It accompanies the technical briefing Secure and Equitable Land Rights in the Post-2015 Agenda The success of the post-2015 sustainable development ...

core  

Forecasting the equity risk premium: The role of technical indicators [PDF]

, 2014
Forecasting the Equity Risk Premium: The Role of Technical Indicators Abstract Do existing equity risk premium forecasts ignore useful information, such as technical indicators? Although academics have extensively used macroeconomic variables to forecast
David E Rapach, Harrison Hong, Mark Grinblatt, Massimo Guidolin, Todd Clark, Jesper Rangvid, Christopher J Neely, Adrian Pagan, Henry Cao, Michael Mccracken, William Brock, George, Jun Tu, Robert Engle, Raymond Kan, Cicf Discussant, John Cochrane, Hank Bessembinder, Pedro Santa-Clara, Jennifer Huang, Miguel Ferreira, Guofu Zhou, Long Chen, Jack Strauss, Bruce Grundy   +24 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Establishment of the key Technical Indicators of Positive Pressure Biological Protective Clothing. [PDF]

J Biosaf Biosecur, 2019
Hao L, Zhang Z, Yi Y, Qi J, Zhou Y, Wu J.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effect of aortic arch type on technical indicators in patients undergoing carotid artery stenting. [PDF]

J Int Med Res, 2019
Shen S, Jiang X, Dong H, Peng M, Wang Z, Che W, Zou Y, Yang Y.   +7 more
europepmc   +1 more source