Results 121 to 130 of about 5,887,141 (213)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Violence as an Obstacle to Development

, 2013
This document is one of a series of technical notes that describe the nature and magnitude of violence in the region, its causes and effects, and how it can be prevented and controlled.
Buvinic, Mayra, Morrison, Andrew
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Transport Sector in Belize

, 2013
This Technical Note was prepared to support the transport sector policy dialogue between the Inter-American Development Bank (IDB) and the Government of Belize.
Granada, Isabel, McNish, Brian
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Overview of the Brazilian PPP Experience from a Stakeholders' Viewpoint

, 2014
This paper reviews the current status of the Inter-American Development Bank (IDB) intervention on PPP in Brazil, including a stakeholders' survey on the performance of the Brazilian PPP program.
Astesiano, Gastón, Queiroz, Cesar, Serebrisky, Tomás   +2 more
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Olecranon bursal repair for chronic traumatic bursitis: a surgical technique

JSES Reviews, Reports, and Techniques
Álvaro Javier Muratore, MD, Nadia Gabotto Loredo, MD, Gonzalo Martín Viollaz, MD, Denise Hammoe, MD, Gómez Rodriguez Gustavo, MD, Diego José Gómez, MD, Alejandro Tedeschi, MD, Gustavo Teruya, MD, Rafael Duran, MD   +8 more
doaj   +1 more source

Two-drilled holes technique facilitates removal of failed dental implants: A technical note

Advances in Oral and Maxillofacial Surgery, 2022
Xiaolin Li, Duohong Zou, Shaoyi Wang
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Impact Evaluation Methods for Social Programs

, 2013
This technical note provides a brief overview of the most commonly used methods to carry out impact evaluation of social programs. Impact evaluation is an indispensable tool to assess whether a program is achieving its objective, how the beneficiaries ...
Regalia, Ferdinando
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