Results 61 to 70 of about 5,887,141 (213)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A user guide for the Excel interface to compute optimal tariff aggregators

, 2021
The AGRODEP Consistent Policy Aggregator Toolbox was created to assist users perform aggregation and tariff reduction senarios. Technical Note 13 provides documentation for the toolbox in the form of a user's guide, which includes information on the ...
http://orcid.org/0000-0003-3644-3498 Laborde Debucquet, David, Laborde Debucquet, David   +1 more
core  

Treatment of hemorrhagic retinal detachment additionally complicated by vitreous hemorrhage in a patient with end-stage renal failure

Annales Academiae Medicae Silesiensis
Introduction: End-stage renal disease (ESRD) is thought to be the cause of a number of retinal conditions such as retinal vein thrombosis, retinal artery occlusion, age-related macular degeneration or serous retinal detachment.
Mikołaj Guzikowski, Sebastian Sirek, Wojciech Rokicki   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A comparison between the PEP 1-1 model and the IFPRI standard model

, 2023
The PEP model is an extension of the widely used EXTER model and is the result of collaboration between Bernard Decaluwé, André Lemelin, Hélène Maisonnave and Véronique Robichaud from the PEP network.
http://orcid.org/0000-0001-9352-9293 Traore, Fousseini, Traoré, Fousseini   +1 more
core  

Technical note: Streamflow seasonality using directional statistics [PDF]

Hydrology and Earth System Sciences
Hydrological fluxes typically vary across seasons with several existing metrics available to characterize their seasonality. These metrics are beneficial when many catchments across diverse climates and landscapes are studied concurrently.
W. R. Berghuijs, K. Hale, H. Beria, H. Beria   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source