Results 101 to 110 of about 526,644 (259)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Multi-Criteria Choosing of Material for Manufacturing a Pressure Relief Valve
Engineering ProceedingsThe paper is dedicated to the multi-criteria choice of an optimal variant of a pressure relief valve with a nominal pressure of 3 bar, manufactured from four different materials.
Velizar Zaharinov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Journal of Manufacturing and Materials ProcessingSurface finishing processes are required to produce the final shape of components made of the silicon-infiltrated silicon carbide composite Cesic® from ECM (Engineered Ceramic Materials GmbH, 85452 Moosinning, Germany).
Achim Rösiger +3 more
doaj +1 more source
Optimization and analysis of cutting parameters using cryogenic media in machining of high strength alloy steel [PDF]
, 2013 In this research, liquid Argon is used as a cryogenic media to optimize the cutting parameters for evaluation of tool flank wear width of Tungsten Carbide Insert (CNMG 120404-WF 4215) while turning high strength alloy steel.
Ali, Liaqat +5 more
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
THE EFFECT OF ENVIRONMENTAL INDICATORS TO THE WASTE TREATMENT SCENARIOS RANKING
Facta Universitatis. Series: Mechanical Engineering, 2015 The selection of an appropriate waste treatment scenario is a complex problem in which a set of environmental, economic, and social criteria must be taken into account.
Biljana Milutinović +4 more
doaj
EnergiesAccurate prediction of photovoltaic performance hinges on resolving the electron density in the P-region and the hole density in the N-region. Motivated by this need, we present a comprehensive assessment of a meshless global radial basis function (RBF ...
Murat Ispir, Tayfun Tanbay
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Applied SciencesCombining Organic Rankine Cycles (ORC) with cooling cycles offers a promising approach to achieving greater outputs within a single system. In this study, a novel directly combined ORC-VCC system has been designed to not only meet the cooling demand ...
Nagihan Bilir Sag, Metehan Isik
doaj +1 more source