Results 91 to 100 of about 2,416,913 (352)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Assessment of proofreading and editing with technical diploma students at Western Wisconsin Technical College - Mauston [PDF]
, 1999 Plan BProofreading and editing are a major component of the Office Assistant program. The practices of proofreading and editing are an integral part of primary skills employers expect from their employees. The ability to proofread and edit a document are
Walsh-Betthauser, Kimberly
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
PENERAPAN TEKNIK MENULIS DI SINI DAN SAAT INI (WRITING IN HERE AND NOW) DALAM PEMBELAJARAN MENULIS CERPEN [PDF]
, 2014 This research is motivated by the implementation of learning to write short stories are intrinsically expressive, but implemented are less productive and actually become an own difficulties for students. Students difficulties in presenting ideas or ideas
Ayu Rinjani, Graditya
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Electronic Conferencing—Its Form, Function and Potential for Technical Writing Instruction
Discourse and Writing/Rédactologie, 1989 Chelva Kanaganayakam
doaj +1 more source
Design and user evaluation of a mobile app to teach Chinese characters. [PDF]
, 2015 This paper presents both the pedagogical design principles and the challenges faced during the development of a mobile app, Chinese Characters First Steps, to support recognising, learning and practising writing Chinese characters at beginners’ level ...
Kan, Qian, Rosell-Aguilar, Fernando
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Implementing a Technical Writing Program: The Algonquin Experience
Discourse and Writing/Rédactologie, 1984 Barry Barclay
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source