Results 121 to 130 of about 714,950 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Should We Proscribe Existential There

Discourse and Writing/Rédactologie, 1996
Lilita Rodman
doaj   +1 more source

Editorial: Design of extended networks for tuning functionality of materials. [PDF]

Front Chem
Alexandrov EV, Kuznetsov AE, Li Y.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Practices of Technical Writing: Bridging the Culture Gaps

Discourse and Writing/Rédactologie, 1995
Michael P. Jordan
doaj   +1 more source

Teaching games for understanding in school handball: a controlled pre-post study with intact Brazilian physical education classes. [PDF]

Front Psychol
Silva RMO, Figueiredo LS, Clemente FM, Kawczyński A, Farias C, Corrêa JCP, Borges EPA, Pedrosa GF, Guimarães JDS, Laporta L, Costa GCT.   +10 more
europepmc   +1 more source

Access to Writing Kit for Engineering Design Reports

, 2017
The “Writing Kit for Engineering Design Reports” is a suite of tools designed to support the development of improved technical writing skills in undergraduate engineering students.
Pritchard, Peggy A., Lubitz, David, Moussa, Medhat, Hundleby, Margaret   +3 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Technical Writing

Physics Bulletin, 1964
openaire   +2 more sources

Using Acronyms in Technical Writing

Discourse and Writing/Rédactologie, 1999
Michael P. Jordan
doaj   +1 more source