Results 81 to 90 of about 436,521 (404)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

United States Army Discharge Certificate [PDF]

, 1946
This certificate from the United States Army states that Bob Jones received an Honorable Discharge from his military service in April of 1946. He was a Technician Fourth Grade in the 3112nd Signal Service Battalion at the time of his discharge. Jones was
Nellis, E. B.
core   +1 more source

Adaptation of a University Soils Mechanics Course for a Union Technician Training Program [PDF]

, 2019
When dealing with the term “geotechnical”, most often engineers associate this with the engineering during the design phase. However, equally important is the quality control performed during the construction phase.
Dobrowski, Thomas J.
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Simulating Realistic MRI variations to Improve Deep Learning model and visual explanations using GradCAM [PDF]

arXiv, 2021
In the medical field, landmark detection in MRI plays an important role in reducing medical technician efforts in tasks like scan planning, image registration, etc. First, 88 landmarks spread across the brain anatomy in the three respective views -- sagittal, coronal, and axial are manually annotated, later guidelines from the expert clinical ...
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Defining the Role of the Pharmacy Technician and Identifying Their Future Role in Medicines Optimisation

Pharmacy, 2017
Background: Traditionally, pharmacy technicians have worked alongside pharmacists in community and hospital pharmacy. Changes within pharmacy provide opportunity for role expansion and with no apparent career pathway, there is a need to define the ...
Melanie Boughen, J. Sutton, Tess Fenn, D. Wright   +3 more
semanticscholar   +1 more source

Care of the Dying: The Doctor and Euthanasia [PDF]

, 1974
The quality of the doctor patient relationship is central in this discussion of the euthanasia problem. Robert Rizzo, Ph.D., is Assistant Professor in the Department of Religious Studies at Canisius College, Buffalo, N.Y.
Rizzo, Robert, Yonder, Joseph
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

AI Technicians: Developing Rapid Occupational Training Methods for a Competitive AI Workforce [PDF]

The accelerating pace of developments in Artificial Intelligence~(AI) and the increasing role that technology plays in society necessitates substantial changes in the structure of the workforce. Besides scientists and engineers, there is a need for a very large workforce of competent AI technicians (i.e., maintainers, integrators) and users~(i.e ...
arxiv   +1 more source