Results 41 to 50 of about 10,817,841 (245)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Methodology and theory evaluation of overall equipment effectiveness based on market

, 2010
Purpose - Continuous manufacturing systems used within the steel industry involve different machines and processes that are arranged in a sequence of operations in order to manufacture the products.
Anvari, Farhad, Starr, Andrew, Andrew Starr, Starr, Andrew G., Farhad Anvari, Rodger Edwards, Edwards, Rodger   +6 more
core   +1 more source

Moderating effects of performance measurement use on the relationship between organizational performance, measurement diversity and product innovation [PDF]

, 2007
This study sets'out to address the question of whether the effect of organizational' performance measurement diversity on product innovation will differ depending on how organizational performance measures are used.
Yaghi , Bassil A.
core   +5 more sources

Generic characterization method for nano-gratings using deep-neural-network-assisted ellipsometry

Nanophotonics
As a non-destructive and rapid technique, optical scatterometry has gained widespread use in the measurement of film thickness and optical constants. The recent advances in deep learning have presented new and powerful approaches to the resolution of ...
Jiang Zijie, Gan Zhuofei, Liang Chuwei, Li Wen-Di   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Productivity and efficiency measurement techniques: Identifying the efficacy of techniques for financial Institutions in developing countries [PDF]

, 2011
The concepts of efficiency have received a great deal of attention in many organisations. Many different approaches have been applied by many researchers to the measurement of efficiency changes in various types of institutions.
Jayamaha, Ariyarathna, Mula, Joseph M.
core  

Performance Measurement Systems, Competitive Priorities, and Advanced Manufacturing Technologies: Some Evidence from the Aeronautical Sector [PDF]

, 2005
Purpose – When acquiring advanced manufacturing technologies (AMT), the greatest caution should be taken regarding the performance measurement system to be used: the decision regarding new investments should not be conditioned by the excessive use of ...
Sacristán Díaz, Macarena, Álvarez Gil, María José, Álvarez, María José, Dominguez Machuca, José A.   +3 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Analysis of Various Techniques for Tooth Shade Matching: An Umbrella Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Precise shade matching plays a crucial part in restorations, as highlighted by the goal of aesthetic excellence in dentistry, which is moulded by social trends and innovative technologies.
S Advaitha Narayan , Madhuram Krishnamurthy, K Shanmugapriya, Ashok Leburu   +3 more
doaj   +1 more source