Results 191 to 200 of about 11,927 (254)

Electro‐Mechanical Uncoupling of KV7.1 Voltage Sensor and Pore by 1,4‐Benzodiazepines Is Modulated by Decoration of Position 1

Archiv der Pharmazie, Volume 359, Issue 7, July 2026.
Loss‐of‐function mutations of the voltage‐gated potassium channel KV7.1 (KCNQ1) can lead to malignant arrhythmia. The effects of five 1,4‐benzodiazepines modified at the lactam on KV7.1 gating were thoroughly analysed by two‐electrode voltage clamp experiments.
Florian Roßner, Thomas Jepps, Bo Hjorth Bentzen, Nathalie Strutz‐Seebohm, Bernhard Wünsch, Guiscard Seebohm   +5 more
wiley   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2028-2048, July 2026.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Galaxy Evolution with Manifold Learning. [PDF]

Entropy (Basel)
Takeuchi TT, Cooray S, Kano RR.
europepmc   +1 more source

Robust Cell Segmentation for Size Distribution Estimation via Synthetic‐Data Training

Biotechnology Journal, Volume 21, Issue 7, July 2026.
Graphical Abstract and Lay Summary This study presents an annotation‐free cell segmentation pipeline for the real‐time monitoring of microbial cell size distributions. By automatically extracting single cells from diluted samples using edge detection and compositing them to create dense synthetic training data, a Mask R‐CNN model was trained without ...
Han Bit Kim, Chaeeun Lee, Naeun Lee, Hyeongseok Han, Chanhun Park, Moo Sun Hong   +5 more
wiley   +1 more source

Preoperative butyrylcholinesterase activity and risk of postoperative delirium: A meta-analysis. [PDF]

World J Psychiatry
Qiu YL, Song C, Huang CW, Shen WG.
europepmc   +1 more source

Comparative Transcriptomic Profiling Reveals Differences in Initiation of Antiviral Response in Low rAAV Producing HEK293 Suspension Cells

Biotechnology Journal, Volume 21, Issue 7, July 2026.
Graphical Abstract and Lay Summary Comparative, time‐resolved transcriptomic profiling of HEK293 producer cell lines identified differences in antiviral signaling and cell cycle regulation between producer phenotypes. Low‐producer exhibited strong interferon‐mediated antiviral responses that may restrict vector production, whereas high‐producers showed
Georg Smesnik, Nikolaus Virgolini, Astrid Dürauer, Nicole Borth   +3 more
wiley   +1 more source

Toward Realistic Autonomous Driving Dataset Augmentation: A Real-Virtual Fusion Approach with Inconsistency Mitigation. [PDF]

Sensors (Basel)
Jung S, Kim M, Oh J, Kim J, Lee KT.
europepmc   +1 more source

A Simulation Study of Inhibition Assay With Theophylline on the Enzymatic Hydrolysis of p‐Nitrophenyl Phosphate With Alkaline Phosphatase in a Continuous Mode of Electrophoretically Mediated Microanalysis

ELECTROPHORESIS, Volume 47, Issue 7, Page 595-604, July 2026.
Inhibition assays in in‐capillary continuous enzymatic reaction were simulated using a MATLAB matrix. The enzymatic hydrolysis of p‐nitrophenyl phosphate (S) with alkaline phosphatase (ALP) was adopted as a model enzymatic reaction, where theophylline (I) was used as a model inhibitor.
Toshio Takayanagi, Asuka Nomoto, Hitoshi Mizuguchi   +2 more
wiley   +1 more source

A Coarse-to-Fine Framework for Oil-Water Interface Measurement in Small-Caliber Transparent Test Tubes. [PDF]

Sensors (Basel)
Zhou B, Zhou Y, Zou J, Lv Z, Zhang W, Wang R, Meng S.   +6 more
europepmc   +1 more source

Specific Deletion of Interleukin‐1 Beta in Microglia Improves Acute Outcome and Modulates Neurogenesis After Ischemic Stroke

Glia, Volume 74, Issue 7, July 2026.
Microglial IL‐1β deletion improves acute outcome and reduces neutrophil recruitment after experimental ischemic stroke. Microglial IL‐1β deletion increases neurogenesis in the subventricular zone after experimental ischemic stroke. ABSTRACT Interleukin‐1 (IL‐1) signaling is a major driver of post‐ischemic neuroinflammation, yet the cell‐ and isoform ...
Alba Grayston, Margarida Baptista, Kelly Wemyss, Ruby Taylor, Grace Cullen, Syeda S. Jafree, Nadim Luka, Joshua R. Cox, Joanne E. Konkel, David Brough, Stuart M. Allan, Emmanuel Pinteaux   +11 more
wiley   +1 more source