Results 121 to 130 of about 74,032 (309)

The numerical calculations of influence of underpinning on foundations settlement

, 2013
The paper presents numerical calculations of the influence of implementation technology for underpinning the footing on settlement, with the use of finite element method.
Mazur, R., Wierzbicki, J., Górski, K., Mazurkiewicz, J., Ignatowicz, R. L.   +4 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Endogenous technological change in climate change modelling

, 2002
This article investigates the impact on optimal CO2 abatement and carbon tax levels of introducing endogenous technological change in a macroeconomic model of climate change.
Van Der Zwaan, B. C C, Schrattenholzer, L., Gerlagh, R., Zwaan, B.C.C. van der, Klaassen, G., van der Zwaan, B.C.C.   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Technological preconditions and calculations feed for the manufacture of brake elements drives cars

, 2015
Сучасний стан розвитку інструментального виробництва, машинобудування вимагає пошуку нових шляхів вдосконалення експлуатаційних та технологічних параметрів деталей машин, що дасть змогу покращити якість продукції, зменшити собівартість її виготовлення ...
Hevko, I.B., Левкович, М.Г., Lewkowicz, M.G., Bosiuk, P.V., Гевко, І.Б., Босюк, П.В.   +5 more
core  

First principles electronic structure calculations of Co2CrBi Heusler system

, 2010
First principles calculation results of a new full Heusler system Co2CrBi in stoichiometric composition were presented. The calculations are based on the density functional theory (OFT) within the spin-polarized generalized gradient approximation (sigma ...
Gokoglu, Gokhan
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Рractical work on the discipline «Dimensional calculations in the design of technological processes of parts manufacturing»

Методичні вказівки до практичних робіт з дисципліни «Розмірні розрахунки при проєктуванні технологічних процесів виготовлення деталей» для студентів спеціальності 131 «Прикладна механіка» освітньої програми «Технології машинобудування» денної та заочної ...
Logominov, Viktor, Honchar, Natalia, Логомінов, Віктор Олексійович, Гончар, Наталя Вікторівна, Тумарченко, Лариса Олександрівна, Tumarchenko, Larisa   +5 more
core  

Quantum mechanical calculations of stoichiometric MgO clusters

, 1993
In this paper, we report the results of ab initio molecular orbital calculations on cube-like (MgO)n clusters (n=1-13). We determine the relative stability of the clusters by analyzing binding energies and dissociation energies involved in the ...
Recio, J. M., Pandey, R., Kunz, A. B., Ayuela, A.   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source