Results 121 to 130 of about 109,849 (309)

Government Subsidies and Business Resilience of Chinese Electric Vehicle Enterprises: The Roles of ESG and Technological Capability

Energies
In the context of increasing global macroeconomic policy uncertainty, the effectiveness of Chinese government subsidies in promoting the business resilience of electric vehicle (EV) enterprises and the sustainable development of the EV industry has ...
Qiu Zhao, Chao Zhang, Zhuoqian Li
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Driving Marketing Performance Through Innovation and Differentiation: The Mediating Role of Technological Capability in Small Metal Firms

Binus Business Review
Small firms in traditional manufacturing industries face significant resource constraints that undermine the direct translation of innovation and differentiation strategies into marketing performance, thereby requiring technological capability as a ...
Gunistiyo Gunistiyo, Deddy Prihadi
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Catching Up, Absorption Capability and the Organisation of Human Capital

In order to identify, assimilate and exploit knowledge spill-overs from technological leaders, lagging countries need absorption capability. The main determinant of absorption capability is the organisation of R&D personnel.
Lankhuizen,Maureen
core  

Subsidiary capability upgrading and parent-subsidiary relationship: insights from a Chinese acquisition in the UK

, 2015
Purpose: - This study aims to explore capability upgrading of EMNE’s subsidiaries in developed countries and how the parent-subsidiary relationship influences such upgrading.
Shaowei He, Khan, Zaheer, He, Shaowei, Zaheer Khan   +3 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Learning to Innovate in Nigeria's cable and wire manufacturing sub-sector: inferences from a firm-level case study

Firm performance is known to be connected to firm-level innovation capability. Innovation capability, in turn, is an output of technological learning. This paper evaluates technological learning among firms in the Cable and Wire manufacturing sub-sector ...
Egbetokun, A, Siyanbola, W, Adeniyi, A
core  

Technological Capability Building in South Korea: Some Lessons for Pakistan [PDF]

Recent economic upheavals raise important questions about the nature of the transformation that has taken place in the East Asian economics. Are these economics really catching up with the West? Is there growth process sustainable?
Javed A. Ansari, Rafique A. Khan
core