Results 121 to 130 of about 467,425 (219)

Single-Cell Sequencing of T cell Receptors: A Perspective on the Technological Development and Translational Application. [PDF]

Adv Exp Med Biol, 2020
Gupta S, Witas R, Voigt A, Semenova T, Nguyen CQ.   +4 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Technological Development in Wholegrain Food Processing. [PDF]

Foods
Nocente F, Gazza L.
europepmc   +1 more source

Analysis of the technical-scientific production of the National Council for Scientific and Technological Development (CNPq) productivity fellows in Pediatrics. [PDF]

Einstein (Sao Paulo), 2020
Klepa TC, Pedroso B.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Core Facility for Supporting Research and Technological Development in Health: A Review of Its Concept and the Brazilian Context. [PDF]

ScientificWorldJournal
Oliveira ABRE, Ramos MS, Martinez-Silveira MS, Pinto CD, Ferreira CV, Machado BAS.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Recent clinical researches and technological development in TIL therapy. [PDF]

Cancer Immunol Immunother
Matsueda S, Chen L, Li H, Yao H, Yu F.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The HELP-UnaG Fusion Protein as a Bilirubin Biosensor: From Theory to Mature Technological Development. [PDF]

Molecules
Sist P, Urbani R, Tramer F, Bandiera A, Passamonti S.   +4 more
europepmc   +1 more source