Results 141 to 150 of about 20,873,422 (384)
Knowledge Flows and Productivity [PDF]
National and international flows of knowledge are fundamental determinants of technological progress. In this article we review the existing literature on knowledge flows and we propose a method for estimating them, based on patent citations.
Giovanni Peri
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Technological Capabilities Asymmetries in Latin American and the Caribbean [PDF]
This paper analyzes the convergence process in Latin America and the Caribbean during the 1960-2005 period. The evidence is not favorable to clear convergence or divergence trends, but to a slight process of convergence until the 1970s, and then global ...
Dabus, Carlos Dario +2 more
core +1 more source
Technical-economic aspects of the use of technological process of deforming broaching [PDF]
, 2020 The article gives a definition of the technical and economic potential of the application of the deforming broaching process. Research of the consequences of introducing deforming broaching into technological processes at manufacturing enterprises is ...
Sardak, Sergii +1 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Proactive monitoring and analysis of technological processes of growing crops in automated greenhouses [PDF]
, 2023 Dmitriy Levonevskiy +2 more
openalex +1 more source
TECHNOLOGICAL COLLABORATION: BRIDGING THE INNOVATION GAP BETWEEN SMALL AND LARGE FIRMS [PDF]
This paper analyses technological collaboration as an input to the innovation processes of SMEs. Technological collaboration may be a useful mechanism to offset some of the weaknesses in SMEs’ resource endowments and bring their innovation capabilities ...
Lluis Santamaria, Maria Jesus Nieto
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source