Results 61 to 70 of about 399,661 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Comparative Frequency Analysis of Maximum Daily Rainfall for a SE Asian Region under Current and Future Climate Conditions

Advances in Meteorology, 2017
The impact of changing climate on the frequency of daily rainfall extremes in Jakarta, Indonesia, is analysed and quantified. The study used three different models to assess the changes in rainfall characteristics.
Velautham Daksiya, Pradeep Mandapaka, Edmond Y. M. Lo   +2 more
doaj   +1 more source

Sorption and mass exchange characteristics of extrudates enriched with cocoa bean shells [PDF]

BIO Web of Conferences
The aim of the experimental work was to determine the sorption isotherms of wheat extrudates enriched with cocoa bean shells at different temperatures (10 °C, 25 °C, 40 °C) and water activities (0.11 to 0.85) using the static gravimetric method.
Kodinova Siyka, Toshkov Nesho, Bozadjiev Bojidar, Delchev Naiden   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Towards a universal framework for heat pump monitoring at scale

Buildings & Cities
As heat pump installation across Europe increases, monitoring system performance on a large scale is key for policy decisions and customer confidence. However, in-situ heat pump monitoring has been found in previous work to be very challenging.
Jenny Crawley, Leon Domoney, Adam O’Donovan, Jez Wingfield, Cristian Dinu, Oliver Kinnane, Paul O’Sullivan   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Control System for Automated Technological Process of Hot Stamping-A Case Study. [PDF]

Materials (Basel), 2023
Wróbel I, Danielczyk P.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Automation of the control system for drying grain crops of the technological process for obtaining biodiesel fuels. [PDF]

Sci Rep, 2023
Eremeeva AM, Ilyushin YV.
europepmc   +1 more source