Results 61 to 70 of about 20,169,449 (332)

ON-LINE MONITORING OF TECHNOLOGICAL PROCESS OF MATERIAL ABRASIVE WATER JET CUTTING

, 2015
Original scientific paper The paper deals with the indirect ways of on-line monitoring of technological processes of cutting. The objective of the study is a design of on-line monitoring system for the cutting technology through an abrasive water jet. In
D. Kinik, B. Gánovská, S. Hloch, P. Monka, K. Monkova, Z. Hutyrová   +5 more
semanticscholar   +1 more source

Technological learning: towards an integrated model [PDF]

, 2001
The acquisition and growth of technological knowledge is fundamental to competitive advantage in the emerging knowledge economy. This article explores the notion of technological learning as a means of developing the capabilities that underpin long term ...
Byrne, S., Seidel, R., Simpson, B.M., Woods, C.   +3 more
core  

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Technological Convergence: a Strategic Perspective [PDF]

The information and communication technologies (ICT) sectors are in a process of technological convergence. Determinant factors in this process are the liberalisation of the telecommunications markets and technological change. Many firms are engaged in a
Borés, Cristina, Saurina, Carme, Torres, Ricard   +2 more
core  

A Peer-to-Peer Architecture for Distributed Knowledge Management. [PDF]

, 2002
Most of the knowledge management systems of complex organizations are based on technological architectures that are in contradiction with the social processes of knowledge creation. In particular, centralized architectures are adopted to manage a process
Bonifacio, Matteo, Cuel, Roberta, Mameli, Gianluca, Nori, Michele   +3 more
core   +2 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Impact of M&A on the R&D process. An empirical analysis of the role of technological and market relatedness, The [PDF]

While the impact of M&A on R&D and innovation examined at the aggregate level left inconclusive evidence, we find that at the level of the R&D process both the technological and the market relatedness between the target and the acquirer are helpful ...
Cassiman, Bruno, Colombo, Massimo, Garrone, Paola, Veugelers, Reinhilde   +3 more
core  

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source