Results 121 to 130 of about 152,989 (306)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2020 In natural aggregates, the particle shape is dependent on the nature of the rock and crushing process which affect the properties of PAM. However, due to the lack of variation in the shape properties in the natural aggregates, the relationship between ...
Yoong, Daryl Wen Kiat
core
Financial Law ReviewThis article analyzes the innovative legal framework of Diia City in Ukraine, designed to foster technological ecosystem growth and attract international investment.
Petro Kornieiev, Ivan Yatskevych
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Simulation Method for Design and Development of Magnetic Shape Memory Actuators
The systems/products and their design processes have become more and more complicated due to the fact that their requirements in terms of function, durability, reliability and energy efficiency have been increased significantly and that their leading ...
Schiepp, Thomas
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The shape of aggregate production functions: evidence from estimates of the World Technology Frontier [PDF]
The article provides multifaceted evidence on the shape of the aggregate country-level production function, derived from the World Technology Frontier, estimated on the basis of annual data on inputs and output in 19 highly developed OECD countries in ...
Jakub Growiec +3 more
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Discover SustainabilityIn the contemporary landscape, environmental degradation and climate change pose formidable challenges for developing economies like India, which has undergone rapid economic expansion over recent decades.
Sana Fatima +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Technological heredity - A decisive factor for tribological features of regenerated gears
, 2014 The reparatory hardfacing of damaged contact surfaces is the most reliable method of renewing the tooth shape, dimensions and operating characteristics of failed gears. Proper selection of method suitable for reparatory hardfacing implies knowledge about
Marković, Svetislav, Lazović, Tatjana
core +1 more source