Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
From processing-centered innovation to analytical diversification: network evolution in virgin olive oil patents. [PDF]
Front Res Metr AnalKarakaya T, Tunca S, Balcioglu YS.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Thaksin’s Legacy: Thaksinomics and Its Impact on Thailand’s National Innovation System and Industrial Upgrading [PDF]
Thaksin Shinawatra was one of the most powerful prime ministers of Thailand. Undergirded by a set of new policies termed Thaksinomics, great political power, his CEO style of management, and his intention to make Thailand a developed country, his ...
Patarapong Intarakumnerd
core
Automation of Monitoring Compliance with Technological Regulations Using the Example of the Process of Filling Petroleum Products. [PDF]
J ImagingSidorov A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Possible technological determinants and primary energy resources of future long waves [PDF]
The purpose of this paper is to conjecture the possible underlying technological determinants of future long waves, based on prominent studies of scholars and leading forecasting companies; in particular, this research assumes the converging of nano-bio ...
Mario Coccia
core
Usability Across 3 mHealth Problem-Solving Training Interventions for Diverse Neurodevelopmental and Neurological Populations: Multicase Usability Evaluation. [PDF]
JMIR Hum FactorsOgundairo D +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The Technological Bias in the Establishment of a Technological Regime: the adoption and enforcement of early information processing technologies in US manufacturing, 1870-1930 [PDF]
This paper presents a qualitative study on the adoption of early information technologies, such as typewriters, calculators or Hollerith machines in US manufacturing in the period between 1870 and 1930, which was by all means a true systemic innovation ...
Reinstaller ,Andreas, Hölzl,Werner
core