Results 201 to 210 of about 521,098 (276)

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

N-Glycosylation Influences the Heterologous Expression of an Unspecific Peroxygenase From Marasmius rotula in Saccharomyces cerevisiae. [PDF]

Microb Biotechnol
Schramm M, Schmidtke KU, Kolaczek Y, Jehmlich N, Hofrichter M, Scheibner K.   +5 more
europepmc   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Label-Free Differentiation of Antimicrobial Resistance Groups Using Raman Spectroscopy. [PDF]

Anal Chem
Pistiki A, Ryabchykov O, Wagenhaus A, Bocklitz TW, Deinhardt-Emmer S, Löffler B, Rösch P, Popp J.   +7 more
europepmc   +1 more source

Vorlesungsverzeichnis. Karlsruher Institut für Technologie (KIT). Sommersemester (SS) 2025

Karlsruher Institut für Technologie (KIT)
core   +1 more source

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Considérations urgentes pour la prévention du suicide dans le cadre d’un emploi sécuritaire et éthique de l’intelligence artificielle. [PDF]

CMAJ
Crawford A, Glatard T.
europepmc   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure. [PDF]

Artif Organs
Marckmann D, Wack E, Schäfer L, Hillebrecht HC, Reimer F, Stöger G, Krötzsch K, Menzel M, Kousoulas L, Utzolino S, Fichtner-Feigl S, Staudacher DL, Arnold F, Welte T, Holzner P, Rottmann FA, Berlin C.   +16 more
europepmc   +1 more source

Deep Residual Combiner: A Learned Fusion of Spatial, Temporal, and Multiscale Correlated Pixel Estimates

Computer Graphics Forum, EarlyView.
Abstract Correlation‐based rendering techniques continue to advance, and efficiently exploiting correlations between pixel estimates has become increasingly important. The deep combiner framework [BHHM20] allows us to fuse independent and correlated pixel estimates but focuses solely on spatial correlations.
W. Zhou, E. Hughes, T. Hachisuka
wiley   +1 more source