Results 91 to 100 of about 5,155,074 (299)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Centre‐loss—A preferred class verification approach over sample‐to‐sample in self‐checkout products datasets

IET Computer Vision
Siamese networks excel at comparing two images, serving as an effective class verification technique for a single‐per‐class reference image. However, when multiple reference images are present, Siamese verification necessitates multiple comparisons and ...
Bernardas Ciapas, Povilas Treigys
doaj   +1 more source

Sketch of Big Data Real-Time Analytics Model [PDF]

, 2015
Big Data has drawn huge attention from researchers in information sciences, decision makers in governments and enterprises. However, there is a lot of potential and highly useful value hidden in the huge volume of data.
Amen, Bakhtiar, Lu, Joan
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Wirelessly Powered Light and Temperature Sensors Facilitated by Electrically Small Omnidirectional and Huygens Dipole Antennas

Sensors, 2019
Wirelessly powered, very compact sensors are highly attractive for many emerging Internet-of-things (IoT) applications; they eliminate the need for on-board short-life and bulky batteries.
Wei Lin, Richard W. Ziolkowski
doaj   +1 more source

Giving neurons to sensors. QoS management in wireless sensors networks [PDF]

, 2006
Public utilities services (gas, water and electricity) have been traditionally automated with several technologies. The main functions that these technologies must support are AMR, Automated Meter Reading, and SCADA, Supervisory Control And Data ...
Barbancho Concejero, Antonio, Barbancho Concejero, Julio, León de Mora, Carlos, Molina Cantero, Francisco Javier   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Data, Technology, and Public Health [PDF]

Public Health Genomics, 2017
Borisch, Bettina, Iloegbu, Chukwuemeka A, Wells, Nadya   +2 more
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source