Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
mHealth Systems Need a Privacy-by-Design Approach: Commentary on "Federated Machine Learning, Privacy-Enhancing Technologies, and Data Protection Laws in Medical Research: Scoping Review". [PDF]
Tewari A.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Point Cloud Data Mining With HD Map Priors for Making Synthetic Forest Datasets
Airbornelaser scanning has proven to be an indispensable tool in surveying outdoor areas due to its efficient land coverage and unimpeded access to difficult-to-reach areas. The spatial information in 3-D point clouds, the data produced in airborne laser
Kasparas Karlauskas +2 more
doaj +1 more source
Return on Investment of RWH technologies in dryland areas of Eastern region of Kenya
The research study evaluated the effectiveness of rainwater harvesting technologies in Eastern Kenya through identifying conditions under which these technologies provide economic opportunities for smallholder farmers in the dryland areas of Eastern ...
Otiende, Verrah +9 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Automated antimicrobial susceptibility testing and antimicrobial resistance genotyping using Illumina and Oxford Nanopore Technologies sequencing data among Enterobacteriaceae. [PDF]
Conzemius R +7 more
europepmc +1 more source
TECHNOLOGIES AND LOCALIZED TECHNICAL CHANGE [PDF]
Heterogenous Technologies, Transformation Function, Localized Technical Change, Production Economics, Research Methods/ Statistical Methods, Q12, O33, C35,
Sauer, Johannes +1 more
core
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Flash Eurobarometer 226 (Data Protection - Data Controllers\u2019 Perceptions)
Attitudes of companies towards data protection issues. Measures of data protection.Topics: assessment of the level of protection of the national Data Protection Law for citizens as sufficient; familiarity with the provisions of the national Data ...
Papacostas, Antonis, European Commission, Brussels DG Communication Public Opinion Analysis Sector
core +1 more source

