Results 71 to 80 of about 5,155,074 (299)

Forecasting the Spreading of Technologies in Research Communities [PDF]

, 2017
Technologies such as algorithms, applications and formats are an important part of the knowledge produced and reused in the research process. Typically, a technology is expected to originate in the context of a research area and then spread and ...
Mannocci, Andrea, Motta, Enrico, Osborne, Francesco   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis

Malaria Journal, 2021
Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an alternative to chloroquine and is considered the most efficacious treatment currently available for uncomplicated falciparum malaria.
Fatoumata O. Maiga, Mamadou Wele, Sounkou M. Toure, Makan Keita, Cheick Oumar Tangara, Randi R. Refeld, Oumar Thiero, Kassoum Kayentao, Mahamadou Diakite, Antoine Dara, Jian Li, Mahamoudou Toure, Issaka Sagara, Abdoulaye Djimdé, Frances J. Mather, Seydou O. Doumbia, Jeffrey G. Shaffer   +16 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Data and Technological Spatial Politics

The chapter traces the contested politics of data, shifting scales from the transnational to the national and local levels: from questions of the (extra-)territoriality of data, the role of jurisdictions and contested ‘technical territories’ to the concrete lived spaces where data are produced, stored, and circulated.
Yaya Baumann, Janna Frenzel, Emanuel Guay, Leonora Indira King, Alex Megelas, Alessandra Renzi, Julia Rone, Sepideh Shahamati, Hunter Vaughan, Tamara Vukov, Rob Kitchin, Jo Bates   +11 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

On the Generation of Synthetic Invoices for Training Machine Learning Models

IEEE Access
Currently, the problem of generating synthetic financial documents is particularly acute. Extending recent research on the topic, we present an enhanced tool for invoice generation.
Rolandas Gricius, Igoris Belovas
doaj   +1 more source

Big Data Visualization Tools

, 2018
Data visualization is the presentation of data in a pictorial or graphical format, and a data visualization tool is the software that generates this presentation. Data visualization provides users with intuitive means to interactively explore and analyze
Bikakis, Nikos
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source