Results 191 to 200 of about 55,692 (297)

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Beyond Accuracy: Advancing ML-Guided Diagnosis of Obstructive Jaundice Through Clinical Integration. [PDF]

Clin Transl Gastroenterol
Rattanapitoon SK, Meererksom T, Thitimahatthanakusol P, La N, Rattanapitoon NK.   +4 more
europepmc   +1 more source

Ultrasensitive Ion‐Imprinted Detection System with Pore‐Depended Electrochemiluminescence Mechanism for Accurate and Rapid Monitoring of Cesium in the Environment

Advanced Science, EarlyView.
This study focuses on the rapid and accurate determination of cesium, a key radioactive contaminant attracting global attention, by creating an ultrasensitive pore‐dependent electrochemiluminescence detection system. It has been successfully applied in the determination of various kinds of environmental samples, exhibiting its significance in the ...
Ziyu Wang, Lei Fang, Jianing Zhao, Chengqi Li, Hebing Xie, Jian‐Bin Pan, Daoben Hua   +6 more
wiley   +1 more source

Image Repeat Analysis in Conventional Radiography in Mobile Clinics: A Retrospective Observational Study. [PDF]

Acta Med Philipp
Alipio MM, Lantajo GMA, Pregoner JDM.
europepmc   +1 more source

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Advanced Science, EarlyView.
An AI‐enabled SERS platform integrates automated exosome enrichment with molecular fingerprinting to enable accurate early detection and differential diagnosis of ten common cancers. The system identifies exosomal dATP as a universal Raman biomarker, offering a scalable, noninvasive, and clinically translatable approach for precision oncology ...
Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen, Jihui Hao   +15 more
wiley   +1 more source

Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report. [PDF]

Am J Case Rep
Kondo S, Abo Qayas W, Hasan O, Tacata RHN, Kobylinski MW, Majewski L.   +5 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Habitat-derived radiomics analysis based on dual lesion for the prediction of microvascular invasion in bifocal hepatocellular carcinoma. [PDF]

BMC Med Imaging
Jia X, Wu F, Liu J, Wang F, Xiao Y, Wu D, Yang C, Zeng M.   +7 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Tuberculosis presenting with necrotic retroperitoneal lymphadenopathy in an immunocompetent patient: A case report and literature review. [PDF]

IDCases
Salcedo AS, Carreras X, Diaz N, Kobayashi T, Alave J.   +4 more
europepmc   +1 more source