Results 131 to 140 of about 33,723,309 (265)

Office of Technology Assessment FY1994 Annual Report to Congress, March 1995

, 1995
The Office of Technology Assessment (OTA) is a nonpartisan congressional support agency of the United States congress. OTA is charged with advising the Congress on a wide range of critical issues involving science and technology.
Office of Technology Assessment
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Health of the Scientific and Technical Enterprise: An Advisory Panel Report to the Office of Technology Assessment [PDF]

, 1978
A report by the Office of Technology Assessment (OTA) on the science and technology fields, with the intent of developing a definition of the enterprise and giving "a framework within which policy makers can assess its health" (p. 3)
United States. Congress. Office of Technology Assessment.
core  

Facilitators of, barriers to and strategies for health-system guidance implementation: a critical interpretive synthesis

npj Health Systems
This study aims to develop a theoretical framework to support the implementation of health-system guidance, contributing to broader efforts to promote evidence-informed policymaking in health systems.
Qi Wang, Junjie Ren, Xinyu Huang, Kehu Yang, Yaolong Chen, Michael G. Wilson, Holger J. Schünemann, John N. Lavis   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Air Transport Technology

, 1982
An assessment by the Office of Technology Assessment (OTA) that "seeks to put in perspective the role and importance of aircraft technology in the total air cargo system" (p. iii)
United States. Congress. Office of Technology Assessment.
core  

Government Involvement in the Innovation Process: A Contractor's Report to the Office of Technology Assessment [PDF]

, 1978
A report by the Office of Technology Assessment covering "the relationship between Government action and technological innovation in the civilian sector of the U.S. economy" (p. 3)
United States. Congress. Office of Technology Assessment.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Impact of Advanced Air Transport Technology

, 1982
An assessment by the Office of Technology Assessment (OTA) that looks at the current situation of the advances made in air transport ...
United States. Congress. Office of Technology Assessment.
core  

Technology and Steel Industry Competitiveness [PDF]

, 1980
A report by the Office of Technology Assessment (OTA) that examines the U.S. steel industry, specifically the "nontechnological factors that shape the environment in which new technology is created and adopted" (p. iii)
United States. Congress. Office of Technology Assessment.
core