Results 41 to 50 of about 29,780,144 (243)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Leveraging Polio Geographic Information System Platforms in the African Region for Mitigating COVID-19 Contact Tracing and Surveillance Challenges: Viewpoint

JMIR mHealth and uHealth, 2022
BackgroundThe ongoing COVID-19 pandemic in Africa is an urgent public health crisis. Estimated models projected over 150,000 deaths and 4,600,000 hospitalizations in the first year of the disease in the absence of adequate ...
Godwin Ubong Akpan, Isah Mohammed Bello, Kebba Touray, Reuben Ngofa, Daniel Rasheed Oyaole, Sylvester Maleghemi, Marie Babona, Chanda Chikwanda, Alain Poy, Franck Mboussou, Opeayo Ogundiran, Benido Impouma, Richard Mihigo, Nda Konan Michel Yao, Johnson Muluh Ticha, Jude Tuma, Hani Farouk A Mohamed, Kehinde Kanmodi, Nonso Ephraim Ejiofor, John Kapoi Kipterer, Casimir Manengu, Francis Kasolo, Vincent Seaman, Pascal Mkanda   +23 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Lessons learnt from decentralization of COVID-19 response in a southwest state of Nigeria

Global Biosecurity, 2022
'Introduction:' This report shows the outcomes and lessons learnt from a 3-month intervention focused on decentralization of COVID-19 coordination, testing and contact tracing activities in three hotspot local government areas (LGAs) of a state in the ...
Adewale Moses Adejugbagbe, Akinola Ayoola Fatiregun, Modupeola Oluwakemi Dosumu, Olaoye Itse, Francis Adegoke Akanbiemu, Stephen Fagbemi, Victor Akinpelumi Adefesoye, Gboyega Famokun, Elvis Isere   +8 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A Typology-Based Approach to Tracing-App Adoption During the COVID-19 Pandemic: The Case of the SwissCovid App

Journal of Quantitative Description: Digital Media, 2021
Contact tracing technology has been introduced in many countries as part of the COVID-19 containment strategy. However, research indicates that current adoption rates are too low for tracing apps to be effective.
Sarah Geber, Thomas Friemel
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

COVID-19 Contact Tracing: Challenges and Future Directions

IEEE Access, 2020
Contact tracing has become a vital tool for public health officials to effectively combat the spread of new diseases, such as the novel coronavirus disease COVID-19.
Mohammad Jabed Morshed Chowdhury, Md Sadek Ferdous, Kamanashis Biswas, Niaz Chowdhury, Vallipuram Muthukkumarasamy   +4 more
doaj   +1 more source

A Multidimensional Analysis of Released COVID-19 Location-Based Mobile Applications

Future Internet, 2021
The spread of coronavirus disease (COVID-19) has triggered a series of responses worldwide ranging from traveling restrictions and shelter-in-place orders to lockdowns, contact tracing, social distancing, and other mitigation measures.
Theodoros Oikonomidis, Konstantinos Fouskas, Maro Vlachopoulou   +2 more
doaj   +1 more source