Results 181 to 190 of about 25,551,850 (384)

User Acceptance of Information Technology: System Characteristics, User Perceptions and Behavioral Impacts

Int. J. Man Mach. Stud., 1993
Fred D. Davis
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Between Hearts and Gears: Technology at the Service of Life. [PDF]

Braz J Cardiovasc Surg
Duarte Junior PC, Murakami AN, Andrade AJP.   +2 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A socio-technical agent-based simulation model for predicting smart agriculture adoption dynamics. [PDF]

Sci Rep
Alotibi YS.
europepmc   +1 more source

Retracted: Optimization of CO Concentration on Mortality of Various Stages of Callosobruchus maculatus and Development of Controlled Atmosphere Storage Structure for Black Gram Grains

Adsorption Science & Technology
Adsorption Science and Technology
doaj   +1 more source

The next 25 years?: future scenarios and future directions for education and technology

, 2010
Keri Facer, Richard Sandford
openalex   +2 more sources

Nanopore sequencing technology, bioinformatics and applications

Nature Biotechnology, 2021
Yunhao Wang, Yue Zhao, Audrey Bollas, Yuru Wang, K. Au   +4 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Correction: Sustainable valorization of fish head wastes into nitrogen-based nutrients: a comparative life cycle assessment. [PDF]

J Biol Eng
Lee S, Ahn S, Zong JH, Oh C, Suh S, Hwang DS.   +5 more
europepmc   +1 more source