Results 181 to 190 of about 6,760,622 (238)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Erratum: Preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions (Erratum). [PDF]

J Biomed Opt
Yan J, Zhuo S, Chen G, Wu X, Zhou D, Xie S, Jiang J, Ying M, Jia F, Chen J, Zhou J.   +10 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Refining the Immersive Technology Evaluation Measure for Virtual Reality Clinical Skills Among Native Arabic-Speaking Medical Students: Qualitative Study. [PDF]

JMIR Med Educ
Alblooshi AS, Almarzooqi FM, Almansoori TM, Punn A, Alameen MG, Kieu A, AlRadini FA.   +6 more
europepmc   +1 more source

Decoding digital transformation in health professions education: a comparative analysis of knowledge, attitudes, and readiness among faculty and students at KSAU-HS. [PDF]

Front Digit Health
Khalil AI, ALyaba LY, Jambi AM.
europepmc   +1 more source

The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals. [PDF]

Brain Imaging Behav
Lu F, Pang Y, Li T, Liu M, Jia C, Gao J, Luo W, Yu Y, Wang L, Tang Q, Cui Q, Gao Q, He Z, Chen H.   +13 more
europepmc   +1 more source