Results 11 to 20 of about 25,551,850 (384)

Using PLS path modeling in new technology research: updated guidelines

open access: yesIndustrial management & data systems, 2016
Purpose – Partial least squares (PLS) path modeling is a variance-based structural equation modeling (SEM) technique that is widely applied in business and social sciences.
J. Henseler   +2 more
semanticscholar   +1 more source

A Theoretical Extension of the Technology Acceptance Model: Four Longitudinal Field Studies

open access: yesManagement Sciences, 2000
The present research develops and tests a theoretical extension of the Technology Acceptance Model (TAM) that explains perceived usefulness and usage intentions in terms of social influence and cognitive instrumental processes.
V. Venkatesh, Fred D. Davis
semanticscholar   +1 more source

The RAST Server: Rapid Annotations using Subsystems Technology

open access: yesBMC Genomics, 2008
BackgroundThe number of prokaryotic genome sequences becoming available is growing steadily and is growing faster than our ability to accurately annotate them.DescriptionWe describe a fully automated service for annotating bacterial and archaeal genomes.
R. Aziz   +25 more
semanticscholar   +1 more source

Technology Acceptance Model 3 and a Research Agenda on Interventions

open access: yesDecision Sciences, 2008
Prior research has provided valuable insights into how and why employees make a decision about the adoption and use of information technologies (ITs) in the workplace.
V. Venkatesh, Hillol Bala
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)

open access: yesNucleic Acids Res., 2013
In 2004, the SEED (http://pubseed.theseed.org/) was created to provide consistent and accurate genome annotations across thousands of genomes and as a platform for discovering and developing de novo annotations.
R. Overbeek   +13 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Technology Roadmap for Flexible Sensors.

open access: yesACS Nano, 2023
Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid ...
Yifei Luo   +141 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

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