Results 61 to 70 of about 21,908,970 (349)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

?????? ???????????? ????????? ?????? ??????????????? ?????? : ????????? ?????? ?????? ??????????????? ???????????? [PDF]

open access: yes, 2019
Department of Management EngineeringFirms participating in printer industries have invested their constrained resources into technology development in order to sustain their competitiveness in the industry.
Lee, Do Hyun
core  

Screen Influences on Preteens [PDF]

open access: yes, 2019
This precis analyzed the works conducted in Southern California in 2014 titled, “Five Days at Outdoor Education Camp Without Screens improves Preteens Skills with Nonverbal Emotion Cues.” The analysis begins by defining non-verbal emotional cues and ...
Noor, Soha
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Identifying Low Carbon Technology for Sustainable Energy Development in Indonesia [PDF]

open access: yes, 2014
As a developing country, Indonesia has voluntarily committed to reduce its green-house gases(GHGs) emissions by 26% with its self-financing, or 41% with addition of foreign aids, by year 2020.This target will carry consequences for Indonesia to make an ...
Kardono, K. (Kardono)
core  

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

The development of technology education internationally [PDF]

open access: yes, 2009
The development of technology education within countries and regions is set within the historical, cultural, and political environment. Curriculum, teacher education, and in fact educational research do not sit in isolation from these.
Jones, Alister
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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