Results 51 to 60 of about 326,799 (264)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring Students’ Intention to Use LINE for Academic Purposes Based on Technology Acceptance Model

International Review of Research in Open and Distributed Learning, 2015
The LINE application is often conceived as purely social space; however, the authors of this paper wanted to determine if it could be used for academic purposes. In this study, we examined how undergraduate students accepted LINE in terms of using it for
Willard Van De Bogart , Saovapa Wichadee   +1 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

(Un)Acceptable!?! [PDF]

Extended Abstracts of the 2018 CHI Conference on Human Factors in Computing Systems, 2018
A central viewpoint to understanding the human aspects of interactive systems is the concept of technology acceptance. Actual, or imagined disapproval from other people can have a major impact on how information technological innovations are received, but HCI lacks comprehensive, up-to date, and actionable, articulations of "social acceptability".
Marion Koelle, Susanne Boll, Thomas Olsson 0002, Julie R. Williamson, Halley Profita, Shaun K. Kane, Robb Mitchell   +6 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

CSL learners’ acceptance and use of ChatGPT: an extended technology readiness and technology acceptance model

Humanities & Social Sciences Communications
As an advanced chatbot based on a large language model, ChatGPT receives widespread attention in the field of education, with its emergence potentially prompting a transformation in language learning methods.
Wei Wei, Yue Xu, Zhimin Wang
doaj   +1 more source

Analyzing Hotel Owners Acceptance of Tiket.com Using Technology Acceptance Model

Jurnal Nasional Pendidikan Teknik Informatika (JANAPATI)
Lombok, a captivating island in West Nusa Tenggara, faces tourism challenges due to the COVID-19 pandemic, causing a decline in visits and revenue. Senggigi, known for its picturesque beaches, experienced a drastic drop in hotel occupancy.
Baiq Dwi Zulianti Kurrotaa'yun, Noor Alamsyah, Helmina Andriani, Santi Ika Murpratiwi   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source