Results 91 to 100 of about 21,434,422 (280)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Elderly Acceptance of Autonomous Vehicles in Malaysia: An Extended Technology Acceptance Model with Multidimensional Trust and Perceived Risk

JOIV: International Journal on Informatics Visualization
The emergence of autonomous vehicle technology is propagated to address the needs of the elderly and reduce other negative externalities brought by transportation mobility. However, these benefits would not be realized without widespread acceptance. This
Jen Sim Ho, Booi Chen Tan, Teck Chai Lau, Nasreen Khan, Suk Min Pang   +4 more
doaj   +1 more source

Analisis Model Penerimaan Teknologi (Technology Acceptance Model) Aplikasi BPJS Online

JEPIN (Jurnal Edukasi dan Penelitian Informatika), 2017
Model penerimaan aplikasi  BPJS Online dalam meningkatkan pelayanan terhadap pengguna jasa yaitu pihak masyarakat melakukan evaluasi manajemen pihak bpjs dengan meminta umpan balik dari masyarakat terhadap penerimaan aplikasi BPJS online.
Marini - Marini, Sarwindah - Sarwindah
doaj   +1 more source

Exploring the Influence of Cultural Values on the Acceptance of Information Technology:  An Application of the Technology Acceptance Model [PDF]

Issues in Informing Science and Information Technology, 2007
While there has been a great deal of research on the application and implementation of Information Technology (IT), there is less research on the variables which can contribute to the successful diffusion and implementation of IT within an organization.
openaire   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Investigating the impact of technology trust on the acceptance of mobile banking technonlgy within Nigeria [PDF]

This empirical study investigates the factors influencing Nigerians’ trust and adoption of mobile banking technology; using an integrative model. Research was conducted using a questionnaire developed and distributed in Nigeria.
Ifeonu, Robert Odera
core   +3 more sources

The Generalization and Specialization of Technology Acceptance Model

, 2012
[[abstract]]Although recent meta analyses of Technology Acceptance Model (TAM) have appeared in the literature, practitioners, students and unseasoned scholars may still encounter difficulties in applying this TAM++ knowledge to real-world technology ...
Tao, Yu-Hui
core