Results 241 to 250 of about 7,254,348 (387)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The association between smartphone addiction and self-esteem among physical education undergraduate students: The chain-mediating roles of professional identity and meaning in life. [PDF]

PLoS One
Sun P, Cui M, Chen X, Yan L.
europepmc   +1 more source

Trends in technological advance: implications for sedentary behaviour and obesity in screenagers [PDF]

, 2010
Griffiths, MD
core  

Genes and (Common) Pathways Underlying Addiction Revealed by Combining and Analyzing Candidate Gene Lists from Multiple Technology Platforms

, 2005
Chuan‐Yun Li, Xizeng Mao, Liping Wei
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The relationship between mobile phone addiction, bedtime procrastination, and campus-based physical activity: a longitudinal follow-up study based on a college student population. [PDF]

Front Psychol
Deng M, Li Z.
europepmc   +1 more source

Young people, online gaming and addiction [PDF]

, 2010
Griffiths, MD
core  

Behavioral addiction to technology.

Technology, Mind, and Behavior
Nicholas David Bowman, C. Shawn Green
openaire   +1 more source

Exploring the Impact of AI Technology Addiction on Stress, Anxiety, and Depression in Adolescents

Cindy C Nadeak, Nurjasni Nurjasni, Helda H Hia, Nurhikmah Siagian, Junianto Sitorus, Atika Anjani, Syamsul Bahri   +6 more
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source