Results 91 to 100 of about 3,095,027 (298)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Research on management and application of tunnel engineering based on BIM technology

open access: yesJournal of Civil Engineering and Management, 2019
The emergence of BIM technology has provided powerful technical means for realizing informatization and digitization in the field of engineering construction, which remarkably promotes the transformation and advance of production and management modes in ...
ZhanPing Song   +5 more
doaj   +1 more source

Editorial: Highlights in sports science, technology and engineering 2021/22. [PDF]

open access: yesFront Sports Act Living, 2022
Düking P   +4 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Technology development in the country with the revision of engineering courses curriculum

open access: yesآموزش مهندسی ایران, 2016
Attention to innovation and technology are important factors in increasing a countny,s economic growth and competitiveness. There is no doubt that science and technology are the most basic elements of economic development, and successful countries are ...
firooz bakhtiari nejad , Nahid Sheikhan
doaj   +1 more source

20180723: College of Information Technology and Engineering, 1995-2017 [PDF]

open access: yes, 2018
These items include materials from the College of Information Technology and Engineering at Marshall University from 1995-2017. Items were received in 2018 and include notable materials from Arthur Weisberg Family Applied Engineering Complex-Grand ...
College of Information Technology and Engineering
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Pengembangan Modul Matematika dengan Pendekatan Science, Technology, Engineering, And Mathematics (STEM) pada Materi Segiempat

open access: yesDesimal, 2018
This study aims to determine the feasibility of mathematical modules with STEM approach and the response of learners and teachers to the attractiveness of the module.
Taza Nur Utami   +2 more
doaj   +1 more source

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