Results 201 to 210 of about 2,140,826 (257)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
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Engineering Antibodies for Biosensor Technologies
2005Publisher Summary The emphasis of this chapter is directed towards the progress made using genetically engineered antibodies that could provide solutions to many of the problems currently associated with the use of conventional antibodies in biosensor systems.
Sarah, Goodchild +3 more
openaire +3 more sources
Annals of Science, 2005
When my home state of New Jersey deregulated its power utilities several years ago, my dad said, “Huh? How can I buy electricity from another company? It's all still the same power lines, so how can another power company send electricity to my house?” I said, “I don't know.” Maybe you know better than I did, and the answer is obvious.
openaire +2 more sources
When my home state of New Jersey deregulated its power utilities several years ago, my dad said, “Huh? How can I buy electricity from another company? It's all still the same power lines, so how can another power company send electricity to my house?” I said, “I don't know.” Maybe you know better than I did, and the answer is obvious.
openaire +2 more sources
Ethics, Technology, and Engineering
2011Featuring a wide range of international case studies, Ethics, Technology, and Engineering presents a unique and systematic approach for engineering students to deal with the ethical issues that are increasingly inherent in engineering practice.
Poel, van de, I.R., Royakkers, L.M.M.
openaire +2 more sources
A technology roadmap for rehabilitation engineering
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005During September 2003, interviews took place to collect data to develop a technology roadmap for rehabilitation engineering. The emerging themes were used to create the roadmap. Criteria were developed to endorse the data prior to the representation process. Added value was by the collection and representation of supporting evidence.
S, Price, R, Summers
openaire +2 more sources