Results 191 to 200 of about 3,080,899 (298)

Beyond genes: CRISPR/Cas9 for chromosomal engineering in polyploids. [PDF]

Front Genome Ed
Jamil M, Mqabool R, Khan SH, Huang WQ, Chen XH.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Overcoming the cytosine base editing barrier: Virus-like particles with uracil-DNA glycosylase inhibition unlocking the clinical potential. [PDF]

Clin Transl Med
Wu Y, Zhu X, Zhu J, Chen J, Hong J.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Corrigendum to "Improved catalytic efficiency of P450 OleP for converting lithocholic acid into murideoxycholic and ursodeoxycholic acids through semi-rational and rational design" [Synth Syst Biotechnol 15 (2027) 94-104]. [PDF]

Synth Syst Biotechnol
Hu B, Pang C, Luo D, Wang Y, Sun C, Zhou J, Chen J, Du G, Zhong F, Zhou J, Wang B, Zhao X.   +11 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Izdavačka djelatnost Fakulteta kemijskog inženjerstva i tehnologije! Edicija ISTAKNUTI PROFESORI [PDF]

Kemija u Industriji, 2008
Kastelan-Macan, Marija, Grzetic, Vesna
doaj  

Correction: Tldi1 deficiency mediates Tlde1 self-toxic effect to regulate the adaptability of <i>Salmonella</i> Typhimurium infection and host immune response in mice. [PDF]

Front Cell Infect Microbiol
Zhang J, Liu C, Chen S, Guo R, Jia Y, Li J, Liao C, Ding K, He L, Shang K.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Analysis and design of CW-LD pumped stable Q-switched laser

Tongxin xuebao, 2004
HUANG Xiu-jiang, SUI Zhan, LI Ming-zhong, LIU Yong-zhi, LI Xin(School of Optic-Electronic Information, Univ. of Electronic Science and Technology of China, Chengdu 610054, China, Laser Fusion Research Center of CAEP, Mianyang 621000, China, School of Electrical Engineering, Univ. of Electronic Science and Technology of China, Chengdu 610054, China)   +14 more
doaj   +2 more sources