Results 51 to 60 of about 2,767,655 (310)
Strategic impact assessment of revitalized science, technology and engineering program
International Journal of Science, Technology, Engineering and MathematicsThe study was conducted to evaluate the revitalized implementation of the Science, Technology and Engineering (STE) program through strategic impact evaluation.
Jerry M. Ortega, Elisa N. Chua
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
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MEDICINE AND ENGINEERING – CONNECTION BIOLOGY, TECHNOLOGY AND INFORMATICS [PDF]
Acta Tecnología, 2017 Biomedical engineering is a broad field that covers a wide range of medical disciplines. Increasingly, nature is linked to engineering and technology. There is a breakthrough in chemical engineering and nanotechnology.
Marianna Trebuňová +2 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Nonlinearity engineering with the Quarton
, 2020 Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, May, 2020Cataloged from the official PDF of thesis.Includes bibliographical references (pages 59-62).In this thesis, we show the principles ...
Ye, Yufeng,S.M.Massachusetts Institute of Technology.
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Innovation Promoted by Meta-Engineering - Mining-Exploring-Converging-Implementing Process [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 The authors propose a new creative concept of “metaengineering” as a dynamic engineering approach that is effective for breakthrough innovation. A science and technology driven country is expected to play a leading role in addressing increasingly more ...
Hiroshi Suzuki, Yuji Okita
doaj
Social assessment of technology and humanitarization of engineering in the information society
RUDN journal of Sociology, 2020 The article considers definitions of the contemporary technology and its social and moral assessment. In the information society, humanitarization of engineering and technical education in general becomes extremely important together with the social ...
V. A Tsvyk, I. V Tsvyk
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