Results 141 to 150 of about 2,140,826 (257)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Revamping Engineering-Design Instructional Computer System
, 2003 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.Includes bibliographical references (leaves 47-49).by Melody T.
Yung, Melody T., 1976-
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Method for Head-shoulder Segmentation and Human Facial Feature Positioning
Tongxin xuebao, 1998 Hu Tianjian Cai Dejun Department of Electrical and Information Engineering (Huazhong University of Science and Technology +1 more
doaj +2 more sources
Development of a reduced-order modeling technique for granular locomotion
, 2019 Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages 87-90).The work is aimed towards the development and expansion of a reduced ...
Agarwal, Shashank(Scientist in mechanical engineering)Massachusetts Institute of Technology.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Laser isotope separation for uranium enrichment : a technology assessment
, 1980 Includes bibliographical references.Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept.
Lester, Richard K. (Richard Keith), 1954-
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of merger and acquisition frameworks from a deal rationale perspective in technology sector
, 2019 Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, 2019Cataloged from PDF version of thesis.Includes bibliographical references.Mergers and Acquisitions (M&A) activity has been a ...
Narayanan, Sridhar,S.M.Massachusetts Institute of Technology.
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source