Results 61 to 70 of about 3,236,767 (307)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Information technology application in intermodal terminal management [PDF]

, 2002
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; and, (S.M.)--Massachusetts Institute of Technology, Dept.
Zhu, Ying, 1975-
core  

Double ESOs-based field-oriented control for PMSM drive system with current sensorless

Journal of Measurement Science and Instrumentation, 2019
A novel double extended state observers（ESOs）-based field-oriented control（FOC） strategy is developed for three-phase permanent magnet synchronous motor（PMSM） drive systems without any phase current sensor. In principle, two current sensors are essential
TENG Qing-fang, CUI Hong-wei, TIAN Jie, School of Automation and Electrical Engineering, Lanzhou Jiaotong University, Key Laboratory of Opto-technology and Intelligent Control   +5 more
doaj  

Review of deterministic networking technology

Dianxin kexue, 2023
Deterministic networking was proposed to meet the demands of high bandwidth, low delay and high reliability for audio and video, industrial control, power protection and other applications.With the development of new services such as virtual/augmented ...
Xiaodong DUAN, Peng LIU, Lu LU, Tao SUN, Zhiqiang LI   +4 more
doaj   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Science, technology, engineering, and mathematics workforce crisis or science, technology, engineering, and mathematics workforce surplus

, 2014
Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2014.Cataloged from PDF version of thesis.Includes bibliographical references (pages 73-77).The science, technology,
Xue, Yi,Ph. D.Massachusetts Institute of Technology.
core  

State science, engineering, and technology program, Georgia

, 1978
Issued as Quarterly reports no. 1-4, Financial statement, and Final report, Project no.
Aton, Carol Lynn
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source