Results 41 to 50 of about 3,080,899 (298)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Strategic impact assessment of revitalized science, technology and engineering program
International Journal of Science, Technology, Engineering and MathematicsThe study was conducted to evaluate the revitalized implementation of the Science, Technology and Engineering (STE) program through strategic impact evaluation.
Jerry M. Ortega, Elisa N. Chua
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
MEDICINE AND ENGINEERING – CONNECTION BIOLOGY, TECHNOLOGY AND INFORMATICS [PDF]
Acta Tecnología, 2017 Biomedical engineering is a broad field that covers a wide range of medical disciplines. Increasingly, nature is linked to engineering and technology. There is a breakthrough in chemical engineering and nanotechnology.
Marianna Trebuňová +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Staying without Power : a case study of the drupal content management system [PDF]
, 2013 Thesis (S.M. in EngIneerIng and Management)--Massachusetts Institute of Technology, Engineering Systems Division, February 2013.Cataloged from PDF version of thesis.
Zhang, Qi, S.M. Massachusetts Institute of Technology. Engineering Systems Division
core
, 1972 Engineering Building, 1972. Photograph originally appears in the Swinburne College of Technology Faculty of Engineering Handbook ...
Swinburne College of Technology
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Innovation Promoted by Meta-Engineering - Mining-Exploring-Converging-Implementing Process [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 The authors propose a new creative concept of “metaengineering” as a dynamic engineering approach that is effective for breakthrough innovation. A science and technology driven country is expected to play a leading role in addressing increasingly more ...
Hiroshi Suzuki, Yuji Okita
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