Results 51 to 60 of about 573,134 (292)

EEG signals analysis using multiscale entropy for depth of anesthesia monitoring during surgery through artificial neural networks [PDF]

, 2015
In order to build a reliable index to monitor the depth of anesthesia (DOA), many algorithms have been proposed in recent years, one of which is sample entropy (SampEn), a commonly used and important tool to measure the regularity of data series. However,
Abbod, MF, Chen, YF, Fan, SZ, Liu, Q, Shieh, JS   +4 more
core   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effectiveness in clinical practice versus efficacy of dipeptidyl peptidase-4 inhibitors in clinical trials for type 2 diabetes: protocol for systematic review

BMJ Open, 2019
Introduction Data supporting the use of oral antidiabetic drugs mainly rely on data from premarketing clinical trials. Real-world data studies are crucial to evaluate effectiveness of drugs.
Francisco Batel-Marques, Diogo Pereira, Diogo Mendes, Ana Penedones   +3 more
doaj   +1 more source

Edited Volumes, Monographs, and Book Chapters in the Book Citation Index (BKCI) and Science Citation Index (SCI, SoSCI, A&HCI) [PDF]

, 2012
In 2011, Thomson-Reuters introduced the Book Citation Index (BKCI) as part of the Science Citation Index (SCI). The interface of the Web of Science version 5 enables users to search for both "Books" and "Book Chapters" as new categories.
Felt, Ulrike, Leydesdorff, Loet
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

What's unusual in online disease outbreak news? [PDF]

, 2010
Background: Accurate and timely detection of public health events of international concern is necessary to help support risk assessment and response and save lives.
Collier, Nigel
core   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Who needs what from a national health research system: Lessons from reforms to the English Department of Health's R&D system [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Health research systems consist of diverse groups who have some role in health research, but the boundaries around such a system are not clear-cut.
A Culyer, A Haines, A Haines, A Harrison, A Irwin, A Kennedy, A Kennedy, Academy of Medical Sciences, Academy of Medical Sciences, AD Kennedy, B Soper, B Wilson, Biosciences Innovation and Growth Team, Bryony Soper, C McCourt, C Pope, C Saunders, C Weiss, C Zarcadoolas, D Cooksey, D Wanless, D Wanless, DC Pelz, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, E West, G McLachan, G Watts, H Nowotny, House of Lords Select Committee on Science and Technology, HTO Davies, I Hargreaves, J Brown, J Darbyshire, J Lavis, J Lexchin, J Lomas, J Lomas, J Lomas, JL Denis, JL Denis, JM Tetroe, JN Lavis, K Stateley, LF Frederiksen, M Buxton, M Buxton, M Buxton, M Gibbons, M Halladay, M Kogan, M Kogan, M Kogan, M Peckham, M Peckham, M Polyani, M Shergold, N Black, N Black, N Fulop, N Mays, N Mays, N Mays, National Institute for Health Research, National Institute for Health Research, National Nursing Research Unit, Nicholas Mays, NIHR Health Technology Assessment Programme, NIHR Service Delivery and Organisation Programme, Office for Strategic Coordination of Health Research (OSCHR), P Dash, PA Diethelm, R Grilli, R Haldane, R Pawson, R Steel, Report Rothschild, S Buckland, S Davies, S Hanney, S Hanney, S Kuruvilla, S Kuruvilla, S Kuruvilla, S Oliver, S Peckham, Service Delivery Organisation (SDO), Shyama Kuruvilla, SPT Hanney, Stephen Hanney, T Milewa, T Pang, UK Clinical Research Collaboration, W Cohen, W Holland   +100 more
core   +6 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Applications of the ACGT Master Ontology on Cancer [PDF]

, 2008
In this paper we present applications of the ACGT Master Ontology (MO) which is a new terminology resource for a transnational network providing data exchange in oncology, emphasizing the integration of both clinical and molecular data.
A. Cali, A. Gómez-Pérez, A.L. Rector, B. Smith, B. Smith, C. Wittekind, J.E. Andrews, J.J. Cimino, K.H. Buetow, L. Martín, M. Tsiknakis, P. Grenon, W. Ceusters, W.A. Schulz   +13 more
core   +3 more sources