Results 141 to 150 of about 3,169,712 (356)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Nursing workforce competencies and job satisfaction: the role of technology integration, self-efficacy, social support, and prior experience. [PDF]
BMC Nurs, 2023 Alshammari MH, Alenezi A.
europepmc +1 more source
Integration of assistive technology in teaching learners with special educational needs and disabilities in the Philippines [PDF]
, 2023 Rolyn Joy Campado +2 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
MetalsFor the application of Ti-6Al-4V alloys in urban air mobility, safety is very important, so achieving excellent strength and toughness is essential to prevent fractures.
Seongji Seo, Minsu Jung, Jiyong Park
doaj +1 more source
Tariffs, Technology and Global Integration [PDF]
In the last two decades tariffs around the globe have fallen significantly. However, less well known are their changes in the sectorial structure of protection rates.
Sebastián Claro
core
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Teachers' Perceptions of Technology Integration in Teaching-Learning Practices: A Systematic Review. [PDF]
Front Psychol, 2022 Akram H +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source