Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Using Core Elements of Health and Safety Management Systems to Support Worker Well-Being during Technology Integration. [PDF]
Int J Environ Res Public Health, 2022 Haas EJ, Cauda E.
europepmc +1 more source
Latest technology trend and Case of Automation/Integration/Optimization Software "iSIGHT"
, 2003 Satoshi Yonezawa
openalex +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Exploring Teachers' Technology Integration Self-Efficacy through the 2017 ISTE Standards. [PDF]
TechTrends, 2022 Gomez FC +3 more
europepmc +1 more source
Production Technology, Information Technology, and Vertical Integration under Asymmetric Information [PDF]
The paper addresses the effect of technological progress on the frontiers of the firm, building on transaction cost theory and agency theory. The model incorporates four types of costs: production, coordination, management, and transaction costs.
Gamal Atallah
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
School learning support for teacher technology integration from a self-determination theory perspective. [PDF]
Educ Technol Res Dev, 2022 Chiu TKF.
europepmc +1 more source
Integration of Computer-Assisted Teaching Technology in English Online Education Platforms [PDF]
Hongjuan Wang
openalex +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source