Results 91 to 100 of about 1,281,035 (364)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Validity and reliability study of the school technology leadership scale according to teachers’ perceptions

International Journal of Assessment Tools in Education
School principals should have school technology leadership skills in order to manage technology integration into teaching and learning activities effectively and efficiently.
Aytac Gogus, Tugba Ögücü
doaj   +1 more source

Technology Leadership Practices of End Users and the Adoption of E-Learning in Midwifery Institutions in Uganda. [PDF]

J Med Educ Curric Dev, 2022
Bigirwa JP, Ndawula S, Naluwemba EF.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CHINA'S RACE TO GLOBAL TECHNOLOGY LEADERSHIP

, 2019
The current trade war between the US and China looks like a small piece in a much larger puzzle over world leadership in which China plays the part of the ascending challenger seeking to upset the existing balance of power. Technology and innovation seem to be Beijing’s weapons of choice in its frontal assault on Washington in sectors traditionally led
openaire   +2 more sources

Walking the Talk: The Impact of High Commitment Values and Practices on Technology Start-ups [PDF]

, 2004
We examine the impact of high commitment work systems (HCWS) on high-technology start-ups. We differentiate two components of a HCWS: the human resource practices and the espoused values of the firm\u27s leadership and demonstrate that both are ...
Burton, M. Diane, O\u27Reilly, Charles
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Big data driven innovation for sustaining SME supply chain operation in post COVID-19 scenario: Moderating role of SME technology leadership. [PDF]

Comput Ind Eng, 2022
Chatterjee S, Chaudhuri R, Shah M, Maheshwari P.   +3 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Distributed Digital Leadership?

MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Im Zuge der wissenschaftlichen Auseinandersetzung mit digitalen Transformationsprozessen (in) der Schule rücken zunehmend auch Führungstheorien und deren Implikationen in den Fokus.
Melanie Schäfer, Ulrike Krein, Christine Haupenthal   +2 more
doaj   +1 more source