Results 121 to 130 of about 1,281,035 (364)

'Triad' or 'Tetrad'? On global changes in a dynamic world. [PDF]

The US-EU race for world leadership in science and technology has become the favourite subject of recent studies. Studies issued by the European Commission reported the increase of the European share in the world's scientific production and announced ...
Debackere, Koenraad, Glänzel, Wolfgang, Meyer, Martin   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Sustainability of Tourism as Development Strategy for Cultural-Landscapes in China: Case study of Ping'an Village

Journal of Rural and Community Development, 2015
This case study explores the challenges associated with tourism development in a village within China's Longji Rice Terrace Scenic Area. We employ Butler's (1980) Tourism Area Life Cycle model as a starting point for understanding the evolution
Courtney Kimmel, Andrew Perlstein, Michael J Mortimer, Dequn Zhou, David P Robertson   +4 more
doaj  

Impact of work environment, leadership, human resources practices and technology on organizations performance

Entrepreneurship and Sustainability Issues
In today's rapidly evolving business landscape, adopting technology plays a pivotal role in shaping the work environment, while effective leadership practices determine how resources are harnessed to achieve organizational goals.
Aida Ahmed Zahrani
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluating site induction practice efficiency and effectiveness:an organisational case study [PDF]

, 2017
The style of induction presentation and other processes, irrespective of duration, immediately establishes the context and attitude of the construction site team and is where initial behavioural standards are established.
Blackwood, David, Gilmour, Daniel, McCartney, Craig, Reynolds, Matthew, Simpson, Edward   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Role Of Leadership in Human Resources Management in the Digital Government Era

Indonesian Interdisciplinary Journal of Sharia Economics
In today's digital era, skilled leadership plays a crucial role in the utilization of information technology. This is in line with the role of human resource management in organizing government operations and public services to run efficiently ...
Artanty Utami, Denny Rakhmad Widi Ashari, Slamet Muchsin, Afiffudin Afiffudin, Muhammad Syahrul Hidayat   +4 more
doaj   +1 more source

Langley aerospace test highlights, 1985 [PDF]

The role of the Langley Research Center is to perform basic and applied research necessary for the advancement of aeronautics and space flight, to generate new and advanced concepts for the accomplishment of related national goals, and to provide ...

core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source