Results 181 to 190 of about 3,253,965 (265)

Modeling music student teachers' behavioral intention of using artificial intelligence in China. [PDF]

Front Psychol
Niu Y.
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Digital Futures in an Ageing Society: Frontline Perspectives on Sociotechnical Imaginaries in Swedish Eldercare. [PDF]

Sociol Health Illn
Morris F, Thelandersson F, Sandberg H.
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

STEPI - Science and Technology Policy Institute

Technikfolgenabschätzung – Theorie und Praxis, 1996
M. Rohr
doaj   +1 more source

Nexus between policy and practice in institutionalization of clinical information systems and knowledge management in developing health systems: Context of tertiary hospitals in Malawi. [PDF]

PLOS Digit Health
Kungwalo EC, Kanjo C, Kunyenje G, Chikumba PA.   +3 more
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Best Practices and Gaps in Current Regulatory and Health Technology Assessment Real-World Evidence Policies for Medicines and Medical Devices: Current State of Play and Next Steps. [PDF]

Clin Transl Sci
Cresswell K, Claire R, Issa L, Kubehl L, Bilal O, Purcell R, Clemente A, Wested J, Jensen LG, Sasane M, Peeters R, Shinkins B, Colvin H.   +12 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source