Results 121 to 130 of about 48,753 (248)

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Pracaxi Oil as a Potential Inhibitor of Fat Bloom

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Fat bloom is one of the major technological challenges faced by the chocolate industry, caused by the polymorphic transition from β2(V) to β1(VI) crystals in cocoa butter (CB). One strategy to slow down this polymorphic transition is the addition of lipids rich in very long chain fatty acids (VLCFA), such as behenic acid.
Victoria Marques Gropelli, Priscila Dayane De Freitas Santos, Thayná Torres Da Silva, Ana Paula Badan Ribeiro, Rosiane Lopes Cunha   +4 more
wiley   +1 more source

Alkali‐Catalyzed Synthesis of Acylglycerol Estolides Exclusively from Castor Oil

Journal of the American Oil Chemists' Society, EarlyView.
This work advances sustainable chemistry by converting renewable castor oil into high‐performance estolides via solvent‐free, low‐energy catalysis. ABSTRACT Estolides are oligomers composed of fatty acid (FA) monomers linked through secondary ester bonds located along the mid‐chain region.
Lucas Natã de Melo, Simoni Margareti Plentz Meneghetti, Mario Roberto Meneghetti, Janaína Heberle Bortoluzzi   +3 more
wiley   +1 more source

Environmental and Genetic Effects on the Composition of Palm Oil From Hybrid Plant Clones of Caiaué and Oil Palm

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT The interspecific hybrids (IEH OxG) obtained from the crossing of Elaeis oleifera (Eo) and Elaeis guineensis (Eg) are resistant to some diseases that affect Eg in some regions of South America, and commercial growing in several countries has been established.
Rosemar Antoniassi, Ricardo Lopes, Sidney Pacheco, Allan Eduardo Wilhelm, Rui Alberto Gomes Junior, Adelia Ferreira de Faria‐Machado, Raimundo Nonato Vieira Cunha   +6 more
wiley   +1 more source

Educacion y tecnologia

, 2001
Actualmente, nuestro país se encuentra inmerso en el proceso de globalización, el cual implica lograr una inserción competitiva en la economía internacional, y a la vez elevar el nivel de la calidad de vida de sus habitantes; para lo cual el Estado costarricense se ha dado a la tarea de redefinir sus políticas públicas, durante los últimos años ...
openaire   +4 more sources

Valorization of Post‐Consumer Waste From Metallized Flexible Packaging and Industrial EPM Waste: Development of Sustainable Composites

Journal of Applied Polymer Science, EarlyView.
Post‐consumer metallized flexible packaging waste and industrial EPM waste are transformed into sustainable composites through mechanical recycling. The incorporation of 30 wt% EPM provides the most favorable balance between stiffness, ductility, and impact resistance, achieving 53.36 kJ/m2.
Tiago O. Oliveira, Samara L. Santos, Ruth M. C. Santana   +2 more
wiley   +1 more source

Revista vol. 1 nº 2 - completo

EaD & Tecnologias Digitais na Educação, 2014
Revista EaD & Tecnologias Digitais na Educação
doaj  

Compositional Time–Temperature–Transformation and Post‐Processing Window Mapping of Epoxy Nanocomposites via Machine Learning

Journal of Applied Polymer Science, EarlyView.
Discrete DSC and rheological data are transformed into continuous compositional Time–temperature–transformation (TTT) diagrams through physics‐informed Gaussian Process Regression. The proposed framework quantitatively predicts post‐gel processing windows across temperature and nanofiller composition, providing a practical route for accelerated design ...
Otávio Bianchi, Dante A. Benvenutti, Leonardo B. Canto, Alessandra Lavoratti, Zainab Al‐Maqdasi, Sandro Campos Amico, Patrik Fernberg   +6 more
wiley   +1 more source

Nº 3 - Completo

EaD & Tecnologias Digitais na Educação, 2015
Revista EaD & Tecnologias Digitais na Educação
doaj